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Identifying sites vulnerable to proteolysis: Initial exploration of the structureactivity relationship (SAR), along with pharmacokinetic experiments, stability assays, and metabolite detection, aids in pinpointing proteolytically susceptible amide bonds within the sequence

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We note that MR-Egger regression has lower statistical power compared to other methods (e.g., IVW) due to its reliance on the Instrument Strength Independent of Direct Effect (InSIDE) assumption and its sensitivity to weak instruments

Semaglutide, for example, can reduce HbA1c by up to 1.8% and weight by up to 6.5 kg

Evidence in humans remains limited and unapproved