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In vivo Release Pharmacokinetic of PSR-MNs for semaglutide After characterizing the mechanical properties and in vitro release profiles of PSR-MNs, we proceeded to evaluate these microneedles in a rat model

That finding surprised many researchers and requires careful interpretation

Given the relatively smaller reduction in body weight (9.4%) in the SELECT trial compared to previous RCTs: 14.9% in STEP1 (BMI 37.86.7 kg/m 2 ) [16] and 13.2% STEP6 (BMI 31.9 kg/m 2 ) [49], pleiotropic effects of semaglutide may contribute to the overall CV risk reduction [25,37]

Note: an older GLP-1, liraglutide (Saxenda) , is also approved for weight management but is being discontinued as newer options take over

Their insufficient insulin secretion in response to glucose stimulation highlights the need for further protocol optimization before clinical translation can be considered a feasible approach [35, 48]

In long-term studies, patients taking Semaglutide GLP-1 lost an average of 15-20% of their initial body weight over periods of one to two years