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Second-generation compounds like semaglutide improved on pharmacokinetic profiles, enabling once-weekly dosing and stronger clinical efficacy

Excessive caffeine can cause anxiety, insomnia, and increased heart rate

Because sublingual bioavailability is lower than injection bioavailability, the actual milligram dose in the drops is higher than the equivalent injectable dose

Phentermine must not be used by individuals with cardiovascular disease, uncontrolled hypertension, glaucoma, hyperthyroidism, psychiatric illness, pregnancy, breastfeeding, or a history of substance abuse

Patients who find this regimen difficult to follow, or who require frequent antacid use, should consult their healthcare provider

Yet, the rapid success of GLP-1s has highlighted an uncomfortable reality