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To view a copy of this licence, visit About this article Cite this article He, Y., Chen, Y., Qian, S

Tier 3: A BMI of 27 to 29.9 plus at least one of these conditions: pre-diabetes, a history of a heart attack, a history of a stroke, or peripheral artery disease

In ACHIEVE-1, 559 patients with type 2 diabetes were randomly assigned to once-daily orforglipron (Eli Lilly) 3 mg, 12 mg, 36 mg or placebo

Side effects peak weeks 6-8

The benefit is in tolerability and consistency, not in enhanced efficacy

According to FDA labeling, exenatide is not recommended in patients with estimated glomerular filtration rate (eGFR) below 30 mL/min/1.73 m
