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At 24 weeks, the mean weight reduction was 17.5% (41.2 lb)

Targeting Ventilatory Instability and High Loop Gain About one-third of patients with OSA have increased ventilatory instability or high loop gain, which is an exaggerated change in ventilatory drive in response to relatively small changes in the partial pressure of carbon dioxide (PaCO 2 ) levels detected by chemoreceptors [12]

Sarson et al., 1984

"Regulatory Decision Summary Rybelsus"

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Consider appetite control vs metabolic support because peptides target specific mechanisms