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Using mouse genetics, cell sorting, proteomics, and single cell transcriptomics, the team linked LSECs mechanistically to GLP-1R-dependent reduction of #Inflammation #Fibrosis #MASH online April 14 in Cell Metabolism by Cell Press Sinai Health Temerty Faculty of Medicine, University of Toronto This work shows that liver improvement is not just a result of weight loss, but part of a broader metabolic reprogramming

A notable impediment to drug development is the lack of biomarkers that could be used to demonstrate target engagement for many of the mechanistic pathways that might be targetable to prevent or treat AD/ADRD

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Kelly Anderson, medical director at Felix, a Canadian telehealth platform that offers prescription weight loss treatments

There were no serious or severe adverse events (AEs) reported, nor discontinuations due to AEs (Table S10)

Breast cancer survivors represent a significant portion of PlexusDx patients, and our clinical team understands the intersection of oncology, metabolic health, and weight management