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Before Tirzepatide, Eli Lilly was a leader in the insulin field but remained in the second tier among global pharmaceutical companies

Most of these "side effects" improve dramatically with adequate water intake

Reduced caloric intake improves insulin sensitivity, reduces liver fat, and lowers inflammatory markers
Rathmacher JA et al

As expected based on its ability to sharply reduce the body weight and normalize the glucose levels, semaglutide lowered the risk of heart attacks, strokes and cardiovascular deaths by as much as 20%

CNS is an important target for improving obesity and many obesity-improving drugs exert effect through the CNS
