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Semaglutide 2.4 mg in participants with metabolic dysfunction-associated steatohepatitis: baseline characteristics and design of the phase 3 ESSENCE trial
Initial therapy with the combination of JANUVIA and metformin provided significant improvements in A1C, FPG, and 2-hour PPG compared to placebo, to metformin alone, and to JANUVIA alone (Table 8, Figure 1)

While some people experience a noticeable decrease in hunger right away, others may need a few weeks of consistent use to observe significant changes
Apovian reports research fundingfrom PCORI and GI Dynamics, Inc