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There may be obstruction of small airways leading to chronic obstructive bronchitis and destruction of the alveolar walls, known as emphysema, resulting in air trapping, dyspnea, and diminished physical capacity

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doi: 10.1210/endrev/bnaa032 [DOI] [PMC free article] [PubMed] [Google Scholar] 63.Christensen M, Vedtofte L, Holst JJ, et al

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