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is a member of the advisory boards for Invex Therapeutics (2020/2021/2022) and Gensight (2022) and declares consultant fees from Invex Therapeutics (Trial Steering Group and Independent Adjudication Committee Fees 2022) and the Velux Foundation (2021), speaker fees from Heidelberg Engineering (2020/2021/2022), Chugai (2021/2022), and Chiesi (2020/2021), royalties/licenses from Springer Publishing: Neuro-Ophthalmology Global Trends in Diagnosis, Treatment and Management

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Variability in body weight and the risk of cardiovascular complications in type 2 diabetes: results from the Swedish national diabetes register

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Liraglutide and semaglutide have beneficial effects on non-alcoholic steatohepatitis.200,201 Additionally, incretin mimetic drugs targeting multiple receptors for greater efficacy, including glucagon and GIP receptors, are under development.202 A Phase 2a study of efocipegtrutide (HM15211), a new long-acting triple GLP-1/GIP/glucagon RA is currently being conducted to assess its use to treat non-alcoholic steatohepatitis.203 Survodutide, a novel dual GLP-1/ glucagon RA, significantly reduced body weight and improved metabolic dysfunction-associated steatohepatitis compared to the placebo in phase II trials.204 Mazdutide, a dual GLP-1/glucagon RA, and retatrutide, a triple GLP-1/GIP/glucagon RA, also have both shown significant weight loss effects in Phase 2 trials.205,206 Among the drugs discussed, including US FDA-approved GLP-1 RAs, tirzepatide was reported to achieve the most significant reduction in blood glucose levels

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