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However, due to rapid inactivation by DPP-4 (132), continuous infusion was required, making it unsuitable for regular use in a real world setting

The new biology and pharmacology of glucagonlike peptide1

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Common gastrointestinal side effects of tirzepatide include: Nausea (1224% of patients, varying by indication and dose) Diarrhea (1218% of patients) Vomiting (510% of patients) Constipation (511% of patients) Abdominal pain or discomfort Decreased appetite Dyspepsia (indigestion) These effects are typically most pronounced during the initial weeks of treatment and during dose escalation periods

And so, there's probably a very intricate set of pathways that sense the GLP-1 and the accessible neurons and then transmit those signals deeper into the brain. So the new study provides some optimism for Parkinsons disease

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