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A recent multicenter study demonstrated that early and aggressive intervention in DKD can delay the progression to ESKD, highlighting the importance of timely therapeutic measures [29]

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All values were converted to cAMP concentration using cAMP standard curve performed parallel and data were subsequently normalised to the response of 100 M forskolin in each cell line, and then normalised to the WT for each agonist

Medical contraindications also restrict eligibility: patients with active pancreatitis, uncontrolled thyroid disease, or severe kidney impairment (eGFR below 15) may not be candidates