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In the placebo condition, participants with obesity showed an imbalance common in overeating: their brain's reward areas lit up when the cue signaled the impending milkshake, indicating heightened craving or wanting, but their neural response during the actual tasting was blunted, indicating reduced liking

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Germany, on the other hand, declined to reimburse semaglutide AOMs even for severe obesity, although it indicated potential consideration for its use in reducing cardiovascular event risk in patients with a history of cardiovascular disease (CVD)