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doi: 10.1186/1758-5996-2-58 44 MuntoniSMereuRAtzoriLMereuAGalassiSCordaSet al

While one case report showed a significant reduction in pain score following the administration of a thoracic splanchnic nerve block followed by radiofrequency thermocoagulation at the T11 and T12 vertebral levels to target parasympathetic neuropathy in a patient with FD, there are no published data for its use in gastroparesis [147]

Those who use the treatment period to fundamentally alter eating patterns, build exercise habits, and address psychological factors around food may have better outcomes after discontinuation than older users set in decades of established patterns

But the full safety profile wont be known until its approved

Fourth, an important issue that is often raised is whether any GLP-1RAs can indeed penetrate the bloodbrain barrier and therefore express any neurobiological activity in the CNS, which would result in cognitive or behavioral changes

A programme of phase 3 trials with retatrutide (TRIUMPH) is ongoing with an aim to assess the safety and efficacy of retatrutide in different populations living with obesity (OSA, T2D, established cardiovascular disease, osteoarthritis)