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More broadly, they challenge the traditional separation between metabolic and psychiatric disease, suggesting peripheral metabolic signals can influence central processes such as motivation and behavior

Patients often report improved blood sugar, reduced medication needs, and more regular menstrual cycles

These effects, which are fundamental for the treatment of simple obesity, take on an even more potentially interesting importance when considered for the treatment of a disease such as lipedema, whose main characteristic seems to be the presence of inflamed, hypo-oxygenated and dysfunctional adipose tissue with fibrosis, extracellular matrix remodeling and lymphatic and vasculature dysfunction [1,35]

Despite obesity being recognized as a chronic, complex disease, insurance and federal programs still do not provide broad coverage to people who live with this disease, the company wrote in a statement

It works by commanding the hypothalamus to shift the body from storage mode into fat-burning mode

JAMA 2022;327:534-545