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Fifth, we provide important data regarding the kidney effects of GLP-1 RAs in patients already treated with SGLT2i

Someone who loses 50 pounds, regains 35 pounds, and maintains 15-pound net loss still shows improvements in blood pressure, lipid profiles, insulin sensitivity, and cardiovascular risk markers compared to never losing weight

The incidence of all-cause blindness was less often coded for individuals with GLP-1 RA prescriptions compared with those without GLP-1 RA prescriptions (2313 [1.2%] vs 3051 [1.6%] events

In contrast, those who took orforglipron regained just 26%, with over two-fifths of participants maintaining over 80% of their body weight reduction

In these patients, we assess weight alongside blood pressure, lipids, glucose, muscle mass, sleep, and bone health, and we consider whether hormone therapy is appropriate alongside or instead of GLP-1 treatment

doi: 10.1056/NEJMoa2206038 47 WillardFSDourosJDGabeMBShowalterADWainscottDBSuterTMet al