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GLP-1 medications cause some patients to eat less than 1,200 calories per day during titration

In further support of a possibly limited role of native GLP1 in the control of ad libitum food intake, a number of studies have shown that GLP1producing PPG neurons are far less responsive to moderate food intake or gastric distension than neighbouring catecholaminergic neurons in the lower brainstem (Kreisler et al., 2014)

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Ensuring equitable access and strengthening health systems will be essential to prevent widening health disparities