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The SURMOUNT clinical trial programme, which included over 2,500 participants, demonstrated that tirzepatide at the 15 mg dose produced an average weight reduction of approximately 2022% of body weight compared to placebo over 72 weeks

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Multivariate linear regression did not show any significant association between rs6923761 or rs761387 GLP1R genotypes and changes in HbA1c, BMI, SBP and DBP

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