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Several mechanisms have been established for PPI-associated bacterial gastroenteritis

5,15,16 GLP-1 RAs reported to improve atherosclerosis by shifting macrophage function and changing inflammatory pathways

Interestingly, in SURPASS-4, the overall cohort of tirzepatide users and those with 30 mg/g UACR experienced an acute dip in eGFR at 12 weeks, resembling the eGFR slope observed in trials with semaglutide and other nephroprotective drugs, such as RAAS blockers [50] and SGLT-2i [51]

Cold or room-temperature dinners (like the tuna bowl or cottage cheese plate) bypass this entirely