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The self-reported 29.3 lbs average weight loss comes from a small, self-selected sample and may not represent typical results

Grimshaw, Craig Gunderson, Shaili Gupta Journal of General Internal Medicine.2026;[Epub] CrossRef Validation and Comparison of ASCVD Risk Score and SCORE2-Diabetes in Japanese Patients with Diabetes Mellitus Yu Suresvar Singh, Yutaka Nakamura, Yuya Matsue, Hanako Inoue, Yuka Akama, Yudai Fujimoto, Taishi Dotare, Taisuke Nakade, Tadao Aikawa, Daichi Maeda, Hirohisa Endo, Akihiro Mochida, Mika Kurita, Fuki Ikeda, Hirotaka Watada, Tohru Minamino International Heart Journal.2026

This includes: [1] Methylphenidate (Concerta, Ritalin) Amphetamine (Dexedrine, Adderall) Non-stimulant medications used to treat ADHD are not controlled substances, as they do not share the same potential for abuse and dependence

Even small reductions in bioavailability due to degradation can meaningfully affect dose response, making it harder to distinguish true therapeutic response from reduced potency