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Although GLP-1R is profoundly found in neurons, a recent study involving mRNA analysis showed its expression in astrocytes and microglia in the cerebral cortex [38]

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Collectively, these mechanisms support the therapeutic potential of GLP-1RAs in preventing and treating SIM (58)

Furthermore, the activation of GLP-1R signaling in the ventromedial hypothalamus (VMH) can also control energy expenditure by promoting food intake-independent weight loss by inducing brown adipose tissue (BAT) thermogenesis and browning through a sympathetic drive to BAT [6]

however, disc pallor is likely to persist [41]