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Regarding the specific dosing regimens, exenatide was administered with a single 20 g loading dose followed by fixed twice-daily injections of 10 g for 12 weeks

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In patients who already produce normal or elevated levels of endogenous GLP-1, flooding those same receptors with long-acting agonists may push a finely tuned system past its adaptive range

Side effects and nausea on GLP-1 can be so severe that polls show many people stop taking the drugs within less than one year

Cao Y, Hlscher C, Hu MM, Wang T, Zhao F, Bai Y, et al

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