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The manifestations of mitochondrial dysfunction in AD mainly include increased oxidative stress and ROS production,152,153 mitochondrial DNA damage,154 mitochondrial respiratory injury,155 and calcium abnormalities.156 Mitophagy,157 mitochondrial dynamics,158 and mitochondrial biogenesis158 are also affected in patients with AD, ultimately resulting in the accumulation of dysfunctional mitochondria and mitochondrial fragmentation

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(This exclusion would no longer have been allowed under the rule change that CMS proposed in late 2024, 36 but that proposal was not finalized.) 33 But while federal Medicare Part D rules expressly prohibit coverage of weight-loss drugs, the Medicaid rules leave that decision up to each state

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By mimicking the actions of the hormone GLP1, these agents improve blood glycaemic control by increasing glucose-dependent insulin secretion, decreasing inappropriate glucagon secretion, and regulate appetite (by increasing satiety and delaying gastric emptying) to promote weight loss