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Research suggests that combined GIP and GLP-1 activation produces synergistic rather than merely additive effects on appetite and reward processing

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Innovative drugs to treat depression : did animal models fail to be predictive or did clinical trials fail to detect effects

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The vascular protective effects of liraglutide were associated with improved plaque stability (14), attenuated endothelial cell dysfunction (14, 15), reduced ICAM-1 expression in the aortic endothelium (12, 15), decreased leukocyte rolling on the endothelium and infiltration of myeloid cells into the vascular wall (13, 16), suppressed foam cell formation (13), and inhibition of vascular smooth muscle cell proliferation (10)