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Both liraglutide and semaglutide have been shown to reduce obesity-induced muscle atrophy via a GLP-1/Sirtuin (SIRT1) pathway in rodents ( in vitro models

All of this happens in a glucose-dependent manner, which means incretin hormonesor their imitators, i.e

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5-12 However, in clinical trials, including SURMOUNT-1 for tirzepatide and STEP 1 for semaglutide, participants were permitted to remain on a given dose for up to 4 additional weeks, as needed, to allow for the dissipation of any GI AEs

Long-term micronutrient monitoring was not routinely conducted in most weight-loss trials