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The tirzepatide before and after data shows similar threshold effects at the 15% mark, reinforcing that this is a physiologically meaningful breakpoint across compound classes

Risk of Depression or Suicidal Thinking Imcivree has caused new or worsening depression and suicidal thinking

GLP-1 and GIP are both secreted in response to food ingestion

The proportion of patients who had ongoing treatment, regardless of previous discontinuation episodes, ranged between approximately 70% and 80% for both drugs during a 15 year period after treatment initiation across analyses using various grace periods

May 8, 2023

Over the previous 12 months, the patient had lost 25 pounds on gradually increasing doses of the phentermine/topiramate combination medication, with very slow weight loss and with an absence of weight loss in the preceding 3 months