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For diabetes, GLP-1 drugs like semaglutide are considered second-line treatments

The dual glucose-dependent insulinotropic peptide and glucagon-like peptide-1 receptor agonist, tirzepatide, improves lipoprotein biomarkers associated with insulin resistance and cardiovascular risk in patients with type 2 diabetes

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Gastroenterology 149 , 389397.e10 (2015)