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Description
As obesity is a key risk factor for type 2 diabetes, cardiovascular disease, and other metabolic disorders, effective pharmacological interventions are increasingly sought after
Discussion The potential of GLP-1 receptor agonists (GLP-1RAs) in addressing binge eating behaviours in BED and bulimia nervosa represents a promising avenue for pharmacotherapy

Christian Wber: has received honoraria consultancy/speaking from Apomedica, Curelator, Eli Lilly, Grnenthal, Hermes, Lundbeck, Novartis, Pfizer, Ratiopharm/Teva, and Stada
Triple Incretin Agonists: Drugs like Eli Lillys retatrutide , which act on GLP-1, GIP, and glucagon receptors, are showing immense promise, with early data suggesting even greater weight loss than tirzepatide

The critical DILI case occurred during rapid dose-escalation studies designed to determine optimal dosing parameters for potential late-stage development

A summary of GLP-1's pleiotropic effects is shown in Fig
