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For a patient on metformin and insulin degludec who cannot use GLP-1 receptor agonists due to pancreatitis history, add an SGLT2 inhibitor with proven cardio...

Introduction The efficacy and safety of oral semaglutide, the first oral glucagon-like peptide-1 receptor agonist, were investigated in patients with type 2 diabetes (T2D) in the Peptide InnOvatioN for Early diabEtes tReatment (PIONEER) programme

Berberine can help maintain normal blood glucose levels by supporting the activity of insulin and glucose uptake in cells, meaning you have more energy after eating and reduced sugar cravings

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Note that DPP-4 normally inactivates GLP-1

doi: 10.1038/s41387-024-00268-4