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Description
GIP Agonism Effect in Diabetic Nephropathy The nephroprotective effect of tirzepatide has not been directly studied, however, the effect of GIP agonism on inflammation has been extensively documented (Figure 2)

2018;41(suppl 1):S73-S85

Methods A literature search was conducted using the major search engines such as PubMed/Medline, Scopus, and Google Scholar, etc

The kidney cancer signal, while intriguing, requires replication and may represent chance, confounding, or true risk

10.1186/S12933-021-01400-9/FIGURES/1 [DOI] [PMC free article] [PubMed] [Google Scholar] Giugliano D., Scappaticcio L., Longo M., Caruso P., Maiorino M

To complement human studies, mouse GIP(3-30)NH 2 was also confirmed as a GIP receptor antagonist with the ability to impair the glucose-lowering effects of human GIP(1-42) in mice (74)
