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Guidelines continue to be revised however, and basal insulin therapy is now often used much sooner and frequently in combination with oral agents or glucagon-like peptide-1 receptor agonists (GLP-1 RAs), rather than postponing insulin therapy until lifestyle modifications and oral agent treatment has failed [2, 3]

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Non-peptide agonists like geniposide show oral bioavailability, broadening therapeutic potential [33]