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Clinical Trials Demonstrating Reductions in Body Weight with GLP-1RAs Several clinical trials have reported that the effects described above resulted in larger reductions in body weight with GLP-1RA therapy compared with placebo in participants with obesity

These include GPCRs such as GPR40, GPR120, and various taste receptors, which respond to the presence of nutrients and trigger the secretion of hormones involved in metabolism

281 Clinical evidence further indicates organ-specific anti-aging effects: semaglutide treatment in individuals with HIV-associated lipohypertrophy resulted in an approximate 3.1-year reduction in biological age, primarily through improvements in the immune/inflammatory system and the brain

In 2025, before the Wegovy pill was approved, the Wegovy injection was approved for treating the liver disease metabolic-associated steatotic hepatitis (MASH)