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The search strategy combined Medical Subject Headings (MeSH) and free-text terms related to GLP-1 receptor agonists, pregnancy, preconception, obesity, polycystic ovary syndrome, and reproductive safety, with Boolean operators (AND, OR) to maximize retrieval

Bliddal M, Nohmie G, Damkier P, Pottegard A

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In the event of any medical emergency, call 911

While previous studies have reported a reduced risk of developing PD in diabetic patients using GLP-1 receptor agonists, likely due to improved glucose metabolism and reduced neuroinflammatory burden, it is important to note that the trials assessing their efficacy in managing PD and included in our analysis applied a diagnosis of diabetes as an exclusion criterion

Different observational studies and case reports have raised concerns about a potential connection between incretin therapy, pancreatitis, and pancreatic cancer