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The leptin-melanocortin axis, the opioid system, glucagon-like peptide-1 (GLP-1)/glucagon-like peptide-1 receptor (GLP-1R) system, and fibroblast growth factor 21 (FGF21)/its receptor complex FGFR1c/-klotho axis are several common pathways confirmed by researches and pharmacological targets that play an essential role in regulating energy balance and feeding behavior (2)

Renal function should be monitored, especially if patients experience significant gastrointestinal symptoms that could lead to dehydration

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Glucagon receptor activation the novel third arm is associated in published research models with increased hepatic lipid oxidation, raised resting energy expenditure, and accelerated reduction of hepatic triglyceride content

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Orforglipron is a selective and potent partial agonist that biases the activation of GLP-1 receptors towards the G-protein signaling pathway and exhibits a lesser ability to recruit -arrestin