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However, Ex had a slightly stronger effect on the consumption of the more palatable food (mean SE average Treatment effect: 15.4 6.5 g against Vehicle and 16.2 9.5 g against Baseline) compared to the effect for the less palatable food ( 2.8 5.9 g against Vehicle and 3.2 6.7 g against Baseline) as supported by a Treatment S2 meal type interaction (using Vehicle days as control: F 1,4 = 12.37, p = 0.025

Entero-endocrine-osseous axis : gastrointestinal hormones as substrates for DPP-4 The initial observation that patients receiving long-term parenteral nutrition develop osteoporosis and osteomalacia raised suspicion about the lack of stimulation for the secretion of incretin hormones in this mode of nutrition and a potential connection between these hormones and bone metabolism [42]

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Tissue distribution and biological functions beyond glucose metabolism: 2.2.1

GLP-1 receptor agonists cause fatigue primarily through indirect mechanisms including substantial caloric restriction from appetite suppression, gastrointestinal side effects leading to dehydration and nutritional deficits, and metabolic adaptation during weight loss

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