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While initial studies indicate it may offer superior weight loss benefits, the long-term safety data are still developing

In contrast, the -cell predominantly expresses another PC isoform, PC2, which yields glucagon (92)

Why the combination increases bleeding risk Eliquis prolongs clotting time by inhibiting factor Xa

Tuttle KR, Lakshmanan MC, Rayner B, et al

Whilst metformin alone rarely causes hypoglycaemia, adding another agent with similar effects may increase this risk, particularly if you are also taking other diabetes medications

Some of these concerns are well-founded, based on clinical data and pharmacological mechanisms