glp 1 receptor agonists beyond their pancreatic effects GLP-1 as Treatments for Type 2 Diabetes GLP-1 | Pancreapedia

Chao CY, Battat R, Al Khoury A, Restellini S, Sebastiani G, Bessissow T

Between 2019 and December 2023 there has been a greater than 932% increase in prescriptions for semaglutide medications

Effect of GLP-1 RAs on LDL-C, HDL-C, and TL levels Studies have shown contradictions regarding the effect of GLP-1 RAs on LDL-C levels in the body, specifically with liraglutide or exenatide

GLP-1RA Mechanism of Action GLP-1 (glucagon-like peptide-1) is a hormone secreted by the intestinal tract during feeding, which enhances insulin secretion and inhibits glucagon secretion in a glucose concentration-dependent manner, and delays gastric emptying to reduce the amount of food eaten through central appetite suppression

Changes are subtle

References 1.Seino Y, Yabe D (2013) Glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1: incretin actions beyond the pancreas