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Many people also report more energy, improved mobility, and a greater sense of confidence and well-being

Liraglutide is the oldest of the three and has the most evidence for antipsychotic-induced weight gain, with positive results from two small RCTs in schizophrenic disorders at a dose of 1.83.0 mg/day (Lee K et al, Gen Hosp Psych 2022;78:5867)

The analyses were performed using Mendelian randomisation (MR) as the primary tool and Summary-data-based Mendelian Randomization (SMR) as an auxiliary validation

By directly acting on appetite circuits in the brain, GLP-1 may cause people to experience less hunger

may number 30 million, which equates to 9% of the overall population

In the retatrutide trials, the ratio of fat loss to lean loss was favorable compared to caloric restriction alone, where lean mass can represent 25-35% of total weight lost