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Can orlistat be added to a GLP1 receptor agonist (GLP1 RA) for weight loss?

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Gastric Emptying: Slows digestion, which promotes sustained satiety

Fu J, Nchambi KM, Wu H, Luo X, An X, Liu D

GLP-1RA optimizes energy allocation priority through "central planning" intervention: Improvement of myocardial energy metabolism: GLP-1 RA activates GLP-1 receptors in myocardial cells, promotes glucose uptake and glycolysis, while inhibiting fatty acid oxidation (FAO), reducing oxidative stress and mitochondrial damage

Until recently, GLP-1RAs would have mostly been the purview of primary care physicians and endocrinologists