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As of now, it is not possible to uncouple the potential benefit of the co-agonists from the additional weight loss

Additionally, the leave-one-out analysis revealed that removing individual SNPs did not substantially alter the overall causal effect estimates (Supplementary Figure S4)
Because there are real limitations, real alternatives, and a real conversation that doesn't always make it into the ads

doi: 10.1056/NEJMoa2511774

Strengths and limitations The primary strength of this analysis is the large, representative population on which the model is based

doi: 10.1016/j.jhep.2020.03.039
