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Those who are sensitive to medications in general often do better with a microdose approach
A recent randomized placebo-controlled trial published by Scirica et al, known as SAVOR-TIMI 53, found no significant difference in ischemic events but did observe higher hospitalizations for heart failure with saxagliptin

Individuals with type 2 diabetes and obesity face a high risk for developing cardiovascular disease and experiencing major cardiac events or conditions, including myocardial infarction, stroke, heart failure, cardiovascular death, and peripheral arterial disease
Historically, the Nobel Prize Assembly has also tended to lean toward honoring basic research
Table 4 Results of a 26-week Trial of Liraglutide Injection as Add-on to Metformin in Adults with Type 2 Diabetes Mellitus a Liraglutide Injection Compared to Sitagliptin, Both as Add-on to Metformin In this 26-week, open-label trial, 665 adult patients with type 2 diabetes mellitus on a background of metformin 1,500 mg per day were randomized to liraglutide injection 1.2 mg once daily, liraglutide injection 1.8 mg once daily or sitagliptin 100 mg once daily, all dosed according to approved labeling
