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None of these clusters are specific to semaglutide- or vehicle-treated HFpEF conditions ( Figure S5B-C ), indicating that semaglutide treatment does not alter the cardiac fibroblast transcriptome to the extent that sample integration, PCA, and Louvain clustering would produce a condition-specific cluster of cardiac fibroblasts

Suppresses appetite (central action): Reduces hunger signals in the brain, leading to decreased food intake and weight loss 1,2

Tirzepatide is a dual-action medication that activates both GLP-1 and GIP receptors, working through two hormonal pathways instead of just one

For researchers currently building protocols based on Phase 2 data, the Phase 3 dose selection validates the 4mg to 12mg range as the therapeutic window
Nutrition and Lifestyle Support Your plan includes guidance on balanced nutrition and sustainable lifestyle changes to support overall wellness
