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Some doctors and health organizations have urged caution when prescribing weight loss drugs to adolescents due to potential mental health risks

Emerging hypotheses also suggest a possible role in reducing lymphedema risk in breast surgery patients undergoing axillary lymph node dissection, with or without immediate lymphatic reconstruction, by preventing obesity-induced mechanical pressure on lymphatic vessels [105]

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Their impact on weight loss outcomes and cardiometabolic health has been transformative, and they remain central to both clinical and commercial strategies