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Aleniglipron was tested in a phase 2a study and a capsule to tablet pharmacokinetic (PK) study was conducted as well
EdU-positive cells were quantified relative to total Hoechst 33,342-stained cells using fluorescence microscopy (Leica, Wetzlar, Germany)

The key pattern is that the reaction should be mild, limited, and getting better instead of spreading or worsening

However, in humans, the contribution of bile acid changes to metabolic improvements after bariatric procedures is less clear

doi:10.1016/j.neures.2006.04.008 102
