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Semaglutide belongs to a class of medicines called GLP-1 receptor agonists

The emergence of dysesthesia as a notable side effect is unique to retatrutide in this comparison

Retatrutide adds a third, and that addition reshapes the whole effect profile

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[8] Early small-scale research suggested it may stimulate lipolysis (the breakdown of fat) and inhibit lipogenesis (fat storage), with preliminary data indicating it may not significantly affect blood glucose or insulin-like growth factor-1 (IGF-1) levels

Its temporary, treatable, and not caused by the medication itself