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There are multiple medications in various phases of research that address different issues such as tolerability, efficacy, dosing, oral delivery, and condition-specific treatment

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In clinical studies, researchers observed that levels of beta-hydroxybutyrate, a direct biomarker of fatty acid oxidation, increased two to threefold in a dose-related pattern at retatrutide doses of 4mg and higher

Even though DPP-4 activity seemed to be the major issue for GLP-1 activity, a breakthrough came from another perspective when Lotte Knudsen from Novo Nordisk developed liraglutide [18]