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[21], to evaluate the certainty of evidence for this outcome

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Tirzepatide is a novel, dual glucose-dependent insulinotropic polypeptide and GLP-1 receptor agonist that is approved in the US as a treatment for type 2 diabetes and under development for long-term weight management, heart failure with preserved ejection fraction and related comorbidities, and nonalcoholic steatohepatitis

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When used concurrently with insulin or insulin secretagogues such as sulfonylureas or meglitinides, the risk of hypoglycemia may be increased, particularly during the initiation of therapy or following dose escalations

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All tirzepatide doses were more efficacious than GLP-1 RAs in achieving a body weight loss of at least 10% and 15% (ESM Table 2)

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FAQs Why is it important to customize GLP-1 medication dosages for patients with chronic kidney disease (CKD)

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