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Description
[21], to evaluate the certainty of evidence for this outcome

Tirzepatide is a novel, dual glucose-dependent insulinotropic polypeptide and GLP-1 receptor agonist that is approved in the US as a treatment for type 2 diabetes and under development for long-term weight management, heart failure with preserved ejection fraction and related comorbidities, and nonalcoholic steatohepatitis

When used concurrently with insulin or insulin secretagogues such as sulfonylureas or meglitinides, the risk of hypoglycemia may be increased, particularly during the initiation of therapy or following dose escalations

All tirzepatide doses were more efficacious than GLP-1 RAs in achieving a body weight loss of at least 10% and 15% (ESM Table 2)

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FAQs Why is it important to customize GLP-1 medication dosages for patients with chronic kidney disease (CKD)
