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About peptides & weight loss

Bioconjug Chem 2018;29:17481755 [DOI] [PubMed] [Google Scholar] 15

Can I stop taking Ozempic once I reach my goal weight

While tirzepatide does not directly target thyroid function, substantial weight loss may affect thyroid hormone requirements in patients on thyroid replacement therapy, as is generally observed with significant weight changes
If you had borderline low testosterone before starting treatment, consider testing levels again at weeks 16 and 32

This mechanistic distinction is considered an important biological basis behind the efficacy differences observed in the Mazdutide vs Semaglutide head-to-head trial presented at ADA 2026
