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These drugs often reduce appetite but can also cause muscle loss.

In the body, semaglutide increases insulin, lowers blood sugar, slows digestion, and suppresses appetite to support weight loss and diabetes control.

However, that is not the reality: even diabetic patients treated with GLP-1 RAs are more likely to stop them than other second-line anti-diabetic medicines.3 That study didnt report why 50% of diabetics on GLP-1 RAs discontinued them, but gastrointestinal (GI) adverse events were a suggested cause.3 Adverse events are just one of a number of reasons that people stop using these drugs, as follows.

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The WHOs announcement came hours after Australia released a safety alert over the potential risk of suicidal thoughts and behaviours for people using the medicines.