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13 In this review, we summarise the evidence related to the effects of GLP-1 RAs on these outcomes ( Figure 1 ), which may shed light on the potential of these agents to be used in the clinical care of HF patients and investigated in large clinical trials to evaluate clinical outcomes

[DOI] [PubMed] [Google Scholar] 30.Tang-Christensen M, et al

Post-marketing surveillance has similarly not identified a strong signal for increased thyroid autoimmunity, though vigilance persists given preclinical findings in rodent C cells

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Drucker commented: GLP1 [drugs] have given us so many wonderful results, but tackling these very challenging brain disorders has been disappointing There was a hope that we would see some benefit, and we didnt. From the Alzheimers Drug Discovery Foundation (ADDF), Howard Fillit, MD, emphasized that even negative trials move the field forward, pointing to the need to target the broader pathobiology of Alzheimers and to consider preventive or combination approaches informed by biomarker profiles